Objective
Professional organic chemist with 5+ years of research experience in high field NMR, high performance liquid chromatography, and X-ray crystallography with a strong interest in medicinal chemistry. Looking to apply my purification and analytical chemistry skills towards solving problems in cancer research.
Education
Ph.D. in Organic Chemistry, 2022
Columbia University
Advisor: John Smith
Thesis: Characterization of novel inhibitors against a TUDOR-domain protein for the treatment of cancer
B.A. in Chemistry cum laude, 2017
University of Florida
Research Experience
Columbia University | Department of Chemistry | 2017 – Present
Research Assistant for Dr. John Smith
- Adapted novel purification methods to a never-before isolated TUDOR-domain protein
- Performed 3 high-throughput drug screens to identify inhibitors of cancer-causing protein 1 (CCP1)
- Mentored 2 junior graduate students and 4 undergraduates in analytical chemistry techniques, resulting in 1 co-authored publication in review and presentations at 3 international conferences
University of Florida | Department of Chemistry | 2013 – 2017
Research Technician for Dr. Max Folgers
- Prepared samples and performed affinity purification mass spectrometry on human cell lines, optimizing protocol for cytoplasmic, membrane-bound, nuclear, and secreted proteins
- Developed code for a protein structure model in Python, incorporating Rosetta data and in-lab cross-linking mass spectrometry data to predict conformations of supramolecular protein complexes
Skills
- Protein purification (HPLC, affinity) and mass spectrometry
- X-ray crystallography
- Programming and statistical analysis in Python, R (advanced)
- Mammalian cell culture
Publications
Webster, J., Johnson, D., Xin, W. et al. X-ray crystallography of a TUDOR-domain protein inhibitor at a novel binding site for use in oncogenic therapy. XXX Journal (2021)
Boris, S., Webster, J., Nemo, F. et al. Simplified protocol for affinity purification followed by mass spectrometry of RTKs in HEK293 cells. XXX Journal (2016)
Fellowships, Awards, and Honors
F31 NRSA Awardee, 2018 – 2022
12% acceptance rate
National Institute of General Medical Science, National Institute of Health
Columbia University Distinguished Graduate Thesis Award, 2022
20% award rate
School of Arts and Sciences, Columbia University
Courses Taught
Introduction to Organic Chemistry
2018 – 2021, Fall Semester
Head Teaching Assistant (lecture section) and Full Lecturer (lab section)
Advanced Seminar in Medicinal Chemistry
Spring 2021
Lecturer
Presentations
“Recent advances in medicinal chemistry” | 2021
Medicinal Chemistry Gordon Research Conference, poster presentation
“TUDOR-domain proteins as targets for cancer therapy” | 2019
Epigenetics and Chromatin Conference at Cold Spring Harbor Laboratories, oral presentation
Professional Affiliations
American Chemical Society
Protein Society
References
Dr. John Smith
Columbia University
3000 Broadway
New York, NY 10027
johnsmith@columbia.edu
Dr. Max Folgers
University of Florida
123 Main Street
Gainesville, FL 32611
maxfolgers@uf.edu
Dr. Maria Curry
Stanford University
364 Lomita Drive
Stanford, CA 94305
mariacurry@stanford.edu